Agenda - Council - 07/23/1991 - Laserfiche WebLink

Home

4, {~C. I~e~roe4E~a~ 1985;34:1-5. ~C, P~flt~n Df ~.t~. MMWR 19B3;32:101M. 7. ~D~. Antt~ to · mtro~ el~cally as~t~ w~th ~ ,~mu~efic~ i~r~e CDC. R~om~ltioni for msllsl~ in lhe ~vmt~ of ~n~tll tranlmlll,on Df human T- t~photroD~ ~ro~. M~R ~n eftKtwe b~m~ ag~nst ch~myO~ tr~chom~tt~ ~ h~ I~mp~x wm~. Abstract ~n Program of 10. Count ~A. S~,cer OW. Smith CD. Ner~ jim~x vt~s transmission: COnDOm StUDieS. Sex ~ronsm Dis 1984:1 Report of the Recommendations of the 1985 DES Task Force of the U.S, Department of Health and Human Services in 19?6, the I./.S. Department of Health. Eclucation. and Welfare set up a DES (diethylstit- bestrOI la synthetic estrogen]) Task Force to rea%aw all aspects of the DES Question ancl to de- vetop recommenctations re~arciing health issues of DES and r~search gaps that exist. In 'J 985. e secorK:l DES Task Force of the U.S. De;~ertm~nt of Health and Human Services [DHH$) was convened to review recent stuclies showir~ a pol:sJbie increased f'isk of breast cancer among women given DES cluring pregnancy and a pos~b~e excess of precancerous abno,,'maiities of the cervix ar,d vagina among women exposed tO DES in utero ( 7 ). BRF_A~T CAN CER Since 197R, results of four investigations re4~vant to this issue have be~n pu~ishe~ 't'wo of these studies were ran0omizecl cLinicat 13~Is re~"tir~ the ior~-tem'n follow-up resuits of the use of DES cJurir~ pregnancy. In of'~, BO diabetic women received hormonal treatment, and 76 diabetic women received placebos. After 29 yea~ of follow-up, four cas. es of breast c. ance~' h~ o. ccu~ among the expos, ed woma. r't. and none. among the unezposeO women in another stucly, 1 0 cases of breast cancer wee fo~'~ amor~ 319 DES-exposed women, and ni~. amon~ 331 ur, exposed wo~men, sugges~r~g the~e was rm excess r~sk. Exposure occurred in the early 1950s. 'Two oDservatior,~3l follow-up sti. K:Jies of won't~n t:r~ated with DF.5 Cluring !~nancy have at~o been reported recently (,~.5). in these stuCLies, the overall relative r~sk of breast cancer emc~n~ the expos~d women ranged from 1.2 to 1.$. erie stt~dy noted that there wes no 20-29 yea~ after ex,sure a~ ~o ~.5 for those fol~w~ 30 years or more [5}. T~ 39~5 Task F~rce c~ncJuO~ that; 3. The~ levels of excess ri~ a~ difficult to ev~te. ~e i~ is difficult to rule out ~urces Df bias that could ~ res~nsJbte for s~h excesses. ~. In the ~o obse~ational st~ie5, the inte~ta[~ in,elves assessi~ whether the excess ~s~5 are Cue to the ~ i~elf Dr tO the i~t~ns f~ the ~ of the O~g. Data fro~ ~o recent st~es ~t that s~ta~us e~ion ~f~e a fi~t ~h is · ~ factor for the ~evetopment of ~ast ca~r (6.7). in the ob~ational studies, ~ ~- ~e~ ink,cat,on of D~5 use was ~eviou5 s~ta~us abomion. The Task Force felt ~uJd be useful to analyze the data on ~5k according to fr~uency of s~ntaneous I